Key cardinal characteristics in FM are generalized widespread pain and hyperalgesia/allodynia 3, and symptoms as fatigue, depression, anxiety, sleep problems, cognitive impairments, headache, and muscle tenderness are often present. This study further confirms that systemic differences in protein expression exist in women with FM compared to controls and that altered levels of specific plasma proteins are associated with different clinical parameters.įibromyalgia (FM) is a chronic complex pain condition with an estimated prevalence of about 1–4% in the general population 1, 2. Pain intensity, PPT, and psychological distress in FM had associations with specific plasma proteins involved in blood coagulation, metabolic, inflammation and immunity processes. Clear significant differences between FM and controls were found in proteins involved in inflammatory, metabolic, and immunity processes. Quantified proteins were analyzed regarding group differences, and correlations to clinical parameters in FM, using multivariate statistics. The plasma proteome profile of FM (n = 30) and controls (n = 32) was analyzed using two-dimensional gel electrophoresis and mass spectrometry. Pressure pain thresholds (PPT) were assessed using an algometer. Clinical variables/background data were retrieved through questionnaires.
The secondary aim was to investigate if plasma protein patterns correlate with the clinical variables pain intensity, sensitivity, and psychological distress.
The primary aim of this study was to investigate the plasma proteome profile in women with FM compared to controls. Fibromyalgia (FM) is a complex pain condition where the pathophysiological and molecular mechanisms are not fully elucidated.
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